# Exploring the interplay among smoking, stress, and negative affect in patients with psychosis: An experience sampling method study

## TL;DR

This study explores how smoking, stress, and negative emotions interact in people with psychosis using real-time data collection.

## Contribution

It reveals short-term emotional effects of smoking in psychosis patients and their siblings using experience sampling.

## Key findings

- Smoking temporarily reduces negative affect in psychosis patients and their siblings.
- The long-term link between smoking and negative affect disappears after accounting for other factors.
- Short-term effects of smoking on emotions may hinder smoking cessation efforts.

## Abstract

Tobacco smoking is highly prevalent in patients with psychosis, who also often experience negative affect (NA) and stress. The relationship between these factors remains unclear in this population. We aimed to investigate everyday life associations in 158 patients with psychosis, 136 unaffected siblings, and 117 controls from the Genetic Risk and Outcome of Psychosis (GROUP) study with Experience Sampling Method measurements.

Generalized linear mixed models were used to evaluate across time and within-subject associations. Across time analyses investigated the relationship between smoking status and overall NA and stress. Within-subject analyses assessed whether smoking between two measurements (t
−1 and t
0) was associated with changes in NA and stress at the measurement after smoking a cigarette (t
0) and at the subsequent measurement (t
+1).

Across assessments, smoking status was initially associated with NA in patients (B=0.26, p=0.036), but this association disappeared after controlling for psychotic symptoms and cannabis use. Within-subject analyses in smokers showed a decrease in NA in patients after smoking (t
0: −0.23, p=0.016), which remained significant after correcting for confounders (t
0: −0.20, p=0.015). Siblings showed a decrease in NA (t
0: −0.22, p=0.009), also after controlling for confounders (t
0: −0.14, p=0.018). No time-lagged effect was found at t
+1 after correction for subsequent smoking.

Overall smoking behavior was not associated with NA in patients with psychosis. In the short term, smoking in the daily life context is associated with a reduction in NA in people vulnerable to psychosis, possibly due to alleviation of withdrawal symptoms, which may complicate smoking cessation.