# Living Labs in digital health: a collaborative ecosystem approach for continuum of care

**Authors:** Tiziana Russo-Spena, Claudia Salvatore, Beth Fairfield, Annachiara Giordano, Serena De Simone, Maddalena Illario

PMC · DOI: 10.3389/fpubh.2025.1728904 · Frontiers in Public Health · 2026-01-06

## TL;DR

This paper explores how Living Labs can be used as collaborative platforms to improve digital health by integrating stakeholder input and enhancing healthcare ecosystems.

## Contribution

The paper introduces the Collaborative Living Ecosystem Approach (CLEA), a new framework for using Living Labs in digital health beyond mere technology testing.

## Key findings

- Living Labs in digital health have three core dimensions: innovation hubs, stakeholder co-creation, and healthcare integration.
- The CLEA framework shifts focus from technology validation to holistic healthcare solutions.
- Stakeholder-driven models and systemic integration are essential for sustainable healthcare innovation.

## Abstract

Living Labs (LLs) are increasingly recognized in healthcare as collaborative environments that drive digital health innovation through stakeholder co-creation in real-world settings. However, existing research has predominantly conceptualized LLs as experimental testbeds for technology validation, neglecting their broader systemic potential in integrated health services.

This study seeks to advance the understanding of LLs in digital health by identifying their foundational elements, analyzing their methodologies, and proposing an expanded framework for their application within healthcare ecosystems.

The study combines a systematic scoping review, guided by PRISMA and based on ENOLL's (2021) six LL principles, with expert focus group discussions. This multi-method design integrates conceptual insights with practical perspectives from digital health contexts.

The study delineates the defining features of LLs in digital health, including their typologies, methodological specificities, stakeholder configurations, intended outcomes, and systemic challenges. These insights inform the Collaborative Living Ecosystem Approach (CLEA), a conceptual framework that reconceptualizes LLs as multidimensional platforms for sustainable healthcare innovation.

CLEA encompasses three core dimensions: a reconceptualization of LLs beyond innovation hubs, a stakeholder-driven model that fosters co-creation, and an emphasis on integrating healthcare services to enhance connectivity across health and care levels. By providing a structured and integrated perspective on LLs, this study contributes to the discourse on digital health ecosystems, shifting the focus from technology validation to holistic, sustainable healthcare solutions that address complex health and societal needs.

## Full-text entities

- **Diseases:** dementia (MESH:D003704), depression (MESH:D003866), dental phobia (MESH:D010698), mental health disorders (OMIM:603663), cardiovascular diseases (MESH:D002318), anxiety (MESH:D001007), diabetes (MESH:D003920), alcohol misuse (MESH:D000437)
- **Chemicals:** Validate (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12816325/full.md

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12816325/full.md

## References

84 references — full list in the complete paper: https://tomesphere.com/paper/PMC12816325/full.md

---
Source: https://tomesphere.com/paper/PMC12816325