# Intravenous leiomyomatosis involving the inferior vena cava and right atrium with postoperative pulmonary embolism: a case report

**Authors:** Yukai Chen, Wangwei Zhang, Aobo Zhuang, Jiaqing Liu, Qinlei Wang, Xiaogang Xia, Wen'gang Li

PMC · DOI: 10.3389/fsurg.2025.1692371 · Frontiers in Surgery · 2026-01-06

## TL;DR

This case report describes a rare uterine tumor that spread to the heart and lungs, leading to a life-threatening complication after surgery.

## Contribution

The report highlights a rare complication of intravenous leiomyomatosis with postoperative pulmonary embolism and emphasizes the importance of multidisciplinary management.

## Key findings

- IVL can extend into the IVC and right atrium, posing significant risks.
- Postoperative pulmonary embolism is a rare but severe complication following IVL surgery.
- Multidisciplinary approaches are essential for diagnosis and treatment of IVL.

## Abstract

Intravenous leiomyomatosis (IVL) is a rare subtype of benign smooth muscle tumor that can exhibit malignant-like biological behavior. Originating in the uterus, IVL grows in mass-like formations within small veins and can extend into the inferior vena cava (IVC), right atrium, and pulmonary arteries. Due to the potential for life-threatening consequences when IVL invades the heart and pulmonary arteries, early diagnosis and radical resection through a multidisciplinary approach are crucial. This report presents a case of uterine intravenous leiomyomatosis involving the IVC and right atrium, complicated by massive pulmonary embolism after surgery, and includes a literature review to discuss the clinical implications.

## Linked entities

- **Diseases:** intravenous leiomyomatosis (MONDO:0003614), pulmonary embolism (MONDO:0005279)

## Full-text entities

- **Diseases:** IVL (MESH:D018231), postoperative pulmonary embolism (MESH:D011655), smooth muscle tumor (MESH:D018235)

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12816260/full.md

## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12816260/full.md

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Source: https://tomesphere.com/paper/PMC12816260