# Relationship between different blood routine parameters and different types of sudden deafness and prognosis

## TL;DR

This study explores how blood parameters relate to sudden hearing loss types and recovery, finding that certain blood markers can predict prognosis.

## Contribution

The study identifies the neutrophil to lymphocyte ratio as an independent predictive biomarker for sudden sensorineural hearing loss prognosis.

## Key findings

- Hemoglobin, neutrophilia, and hypoalbuminemia are positively linked to better prognosis.
- Lymphocytosis and platelet count are inversely associated with prognosis.
- Neutrophil to lymphocyte ratio is a key independent predictor after adjusting for other factors.

## Abstract

This retrospective observational analysis examined the relationship between blood routine parameters and audiometric subtypes of sudden sensorineural hearing loss and prognosis. The 379 participants were then divided into groups according to audiometric configuration, time of onset of symptoms, and prognosis at 4 weeks after therapy. Hemoglobin, neutrophilia, lymphopenia, monocytosis, thrombocytosis, and hypoalbuminemia were positively associated with prognosis, while lymphocytosis, platelet count, age, gender, ASA physical status, obesity, chronic illnesses, chronic kidney disease, diabetes mellitus, hypertension, dyslipidemia, and smoking were inversely associated. The independent predictive biomarker was identified as neutrophil to lymphocyte ratio after adjusting for the other indices, such as C-reactive protein and erythrocyte sedimentation rate. Finally, we examined the relationships between the recovery prognosis and symptom onset time, corticosteroid use, and hearing loss. The results have highlighted that a combined assessment with hematological and inflammatory markers will provide better prognosis prediction and enhance the SSNHL treatment approaches.