# Some aspects of trypsin’s involvement in the regulation of physiological functions

**Authors:** I. V. Kuzmina, S. M. Tolpygo, V. G. Vertiprakhov

PMC · DOI: 10.3389/fmolb.2025.1750770 · Frontiers in Molecular Biosciences · 2026-01-06

## Full-text entities

- **Genes:** ACE (angiotensin I converting enzyme) [NCBI Gene 613133], TMPRSS15 (transmembrane serine protease 15) [NCBI Gene 427967] {aka PRSS7}, REN (renin) [NCBI Gene 100524822], AGT (angiotensinogen) [NCBI Gene 100157073], F2 (coagulation factor II, thrombin) [NCBI Gene 395306] {aka prothrombin}, F2RL1 (F2R like trypsin receptor 1) [NCBI Gene 2150] {aka GPR11, PAR2}
- **Diseases:** hypotensive (MESH:D007022), necrosis of the skin and oral mucosa (MESH:C565008), disorders of the central nervous system (MESH:D002493), necrotizing pancreatitis (MESH:D019283), gastroenteritis (MESH:D005759), inflammatory (MESH:D007249), mycotoxicosis (MESH:D015651), irritable bowel syndrome (MESH:D043183), inflammatory bowel diseases (MESH:D015212), exocrine insufficiency of the pancreas (MESH:D010188)
- **Chemicals:** NO (MESH:D009569), citrinin (MESH:D002953), water (MESH:D014867), L-NAME (MESH:D019331), T-2 toxin (MESH:D013605), HT-2 toxins (MESH:C012351), AFB1 (MESH:D016604), ochratoxin A (MESH:C025589), fumonisin B1 (MESH:C056933), zearalenone (MESH:D015025), Fe(NO)n (-)
- **Species:** Sus scrofa (pig, species) [taxon 9823], Capra hircus (domestic goat, species) [taxon 9925], Gallus gallus (bantam, species) [taxon 9031], Bos taurus (bovine, species) [taxon 9913], Oryctolagus cuniculus (domestic rabbit, species) [taxon 9986], Homo sapiens (human, species) [taxon 9606], Rattus norvegicus (brown rat, species) [taxon 10116]

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## References

30 references — full list in the complete paper: https://tomesphere.com/paper/PMC12816208/full.md

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Source: https://tomesphere.com/paper/PMC12816208