# Adenoid basal carcinoma of the uterine cervix: a case report

## TL;DR

This case report describes a rare cervical cancer in a 65-year-old woman, highlighting its diagnosis and favorable outcome after surgery.

## Contribution

The novelty lies in presenting a detailed immunohistochemical analysis of adenoid basal carcinoma with HPV co-infection and no recurrence over four years.

## Key findings

- The patient tested positive for HPV types 16, 35, and 56.
- The diagnosis of adenoid basal carcinoma was confirmed with a focal high-grade squamous intraepithelial lesion.
- No recurrence or metastasis was observed during four years of follow-up.

## Abstract

Adenoid basal carcinoma (ABC) is a rare human papillomavirus (HPV)-related malignancy of the uterine cervix that predominantly affects postmenopausal women, and it is a low-grade tumor with a favorable prognosis. This report presents a case of ABC along with a detailed immunohistochemical analysis.

A 65-year-old woman tested positive for HPV types 16, 35, and 56 during routine screening. A subsequent cervical biopsy indicated adenocarcinoma. The patient was asymptomatic. She underwent radical hysterectomy, bilateral salpingo-oophorectomy, and bilateral pelvic lymph node dissection. A comprehensive pathological examination of the hysterectomy specimen confirmed ABC with a focal component of high-grade squamous intraepithelial lesion (HSIL). The postoperative course was uneventful, and no recurrence or metastasis was observed during 4 years of follow-up.

Adequate tissue sampling and appropriate immunohistochemical profiling are valuable for accurate diagnosis and differentiation of ABC from other malignant cervical lesions.