# The development of a therapeutic strategy for post-acute sequelae of COVID-19 should be based on an efficient classification of pathogenesis

## TL;DR

This paper suggests that treating long-term effects of COVID-19 needs better classification based on disease causes.

## Contribution

The paper introduces a classification framework for PASC based on distinct pathogenesis types.

## Key findings

- Symptom-based classification may overlook recovery potential in specific PASC subgroups.
- Future research should categorize PASC by underlying pathogenesis for better treatment strategies.
- Four key pathogenesis types are identified for guiding patient enrollment in clinical trials.

## Abstract

The treatment of post-acute sequelae to COVID-19 (PASC) remains challenging. Defining PASC solely based on symptoms and disease duration in clinical trials can mask the potential for recovery in specific patient subgroups. A good design for future research requires a clear classification of various PASC according to different pathogenesis under the general diagnosis. Here, we discuss four key types of pathogenesis that should be recognized to determine the enrollment of PASC patients.