# Case Report: Mucoepidermoid carcinoma of the lung, a challenging diagnosis of an unusual case

**Authors:** María C. Garijo Martínez, Alejandro Olivares-Hernández, Lorena Bellido Hernández, Fernando L. Begliardo, Daniel Morchón-Araujo, Jonnathan Roldán Ruiz, Juan Carlos Redondo González, Luis Posado Domínguez, Eva Campaña Díaz, Inés María de Dios Franco, Emilio Fonseca Sánchez, Edel del Barco Morillo

PMC · DOI: 10.3389/fonc.2025.1626604 · 2026-01-06

## TL;DR

A rare case of low-grade mucoepidermoid lung cancer was successfully diagnosed and treated through multidisciplinary collaboration.

## Contribution

Highlights the successful diagnosis and management of a rare lung cancer subtype through multidisciplinary tumor board discussion.

## Key findings

- Mucoepidermoid carcinoma of the lung is extremely rare and challenging to diagnose.
- Low-grade mucoepidermoid carcinoma can be effectively treated with surgery alone, without further treatment.
- Multidisciplinary tumor boards are crucial for accurate diagnosis when tissue sampling is difficult.

## Abstract

Lung cancer comprises several types of tumors, with the most common subtypes being adenocarcinoma and squamous cell carcinoma. Mucoepidermoid carcinoma of the lung is an extremely rare entity, whose diagnosis and treatment are challenging.

We reported a 55-year-old woman who was diagnosed in the context of a respiratory disease with a mucoepidermoid carcinoma of the lung. The diagnosis was not easy due to the difficulty in obtaining a correct tissue sample to study. After discussing the case in a multidisciplinary tumor board, the patient underwent surgery with the exceptional diagnosis of a low-grade mucoepidermoid carcinoma of the lung. Since then, the patient has been on follow-up, with no evidence of disease.

There are some subtypes of lung cancer with very different behavior from the classical ones. For example, mucoepidermoid carcinomas of the lung have an exceptional survival with surgery, without needing further treatment, when they are classified as low-grade. This case report underscores the importance of an appropriate diagnosis based on the work of multidisciplinary tumor boards, even when there are difficulties in obtaining a tissue sample, to offer to the patients the best opportunities.

## Linked entities

- **Diseases:** mucoepidermoid carcinoma (MONDO:0003036), lung cancer (MONDO:0005138), respiratory disease (MONDO:0005087)

## Full-text entities

- **Diseases:** Mucoepidermoid carcinoma of the lung (MESH:D018277), squamous cell carcinoma (MESH:D002294), adenocarcinoma (MESH:D000230), Lung cancer (MESH:D008175), tumor (MESH:D009369), respiratory disease (MESH:D012140)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12815821/full.md

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Source: https://tomesphere.com/paper/PMC12815821