# Effects of phased focused nursing on liver function and self-care ability in chronic hepatitis B patients

**Authors:** Dongcang Hou, Fei Liu, Dongjie Hou, Chunrong Ping, Wenying He, Zeyang Chen, Ganlu Tian, Tian Qin, Wenjing Zhou, Menghui Xu, Xiaoman Ruan

PMC · DOI: 10.3389/fmed.2025.1679180 · 2026-01-06

## TL;DR

This study shows that phased focused nursing improves liver function and self-care in patients with chronic hepatitis B compared to routine nursing.

## Contribution

The study introduces phased focused nursing as a multidimensional approach that outperforms routine nursing in managing CHB.

## Key findings

- Phased focused nursing significantly lowers AST, ALT, and TBil levels in CHB patients.
- The intervention improves psychological resilience, self-care ability, and quality of life in CHB patients.
- Patients receiving phased focused nursing show better sleep quality and treatment compliance.

## Abstract

Chronic hepatitis B (CHB) patients often face challenges related to liver function recovery, psychological wellbeing, and self-care ability during treatment. Conventional routine nursing may not comprehensively address these multi-dimensional issues. This study aimed to investigate the effects of phased focused nursing on liver function and self-care ability in patients with CHB.

A total of 120 CHB patients who received treatment in our hospital from March 2023 to March 2024 were selected and randomly divided into a control group and a study group. The control group received routine nursing, while the study group received phased focused nursing in addition to routine nursing. Liver function, psychological resilience, self-care ability, subjective wellbeing, quality of life, sleep quality, treatment compliance, and nursing satisfaction were compared between the two groups before and after the intervention.

After the one-month intervention, the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin (TBil) were lower in the study group than in the control group (p < 0.01). In addition, the scores of the Connor–Davidson Resilience Scale (CD-RISC), Exercise of Self-Care Agency (ESCA) scale, and World Health Organization Quality of Life-BREF (WHOQOL-BREF) scale were higher in the study group than in the control group (p < 0.01). Compared to the control group, the study group had higher scores for positive emotions and lower scores for negative emotions on the Memorial University of Newfoundland Scale of Happiness (MUNSH) after the one-month intervention (p < 0.01). Furthermore, the Pittsburgh Sleep Quality Index (PSQI) scores in the study group were lower compared to the control group (p < 0.01). Compared to the control group, treatment compliance and nursing satisfaction were higher in the study group (p < 0.01 and p = 0.01).

Phased focused nursing can significantly improve liver function and has a profound impact on enhancing psychological resilience, sleep quality, self-care ability, subjective wellbeing, and quality of life. Additionally, it enhances treatment compliance and increases nursing satisfaction, indicating its superiority over routine nursing in the multidimensional management of CHB patients.

## Linked entities

- **Diseases:** chronic hepatitis B (MONDO:0005344)

## Full-text entities

- **Genes:** SLC17A5 (solute carrier family 17 member 5) [NCBI Gene 26503] {aka AST, ISSD, NSD, SD, SIALIN, SIASD}, GPT (glutamic--pyruvic transaminase) [NCBI Gene 2875] {aka AAT1, ALT, ALT1, GPT1, SGPT}
- **Diseases:** CHB (MESH:D019694)
- **Chemicals:** TBil (MESH:D001663)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12815744/full.md

---
Source: https://tomesphere.com/paper/PMC12815744