# Synovial Sarcoma Arising From the Falciform Ligament

**Authors:** Amelia J Cooper, Magdalena Sejka

PMC · DOI: 10.7759/cureus.99576 · 2025-12-18

## TL;DR

A rare case of synovial sarcoma originating from the falciform ligament in a 64-year-old man is reported, highlighting the tumor's aggressive nature and limited treatment response.

## Contribution

This paper presents a rare case of synovial sarcoma arising from an unusual anatomical location, the falciform ligament.

## Key findings

- The tumor was locally invasive and extended into the mediastinum and pericardium.
- Neoadjuvant chemotherapy resulted in only a partial response and progression of metastatic disease.
- Surgical resection was not feasible due to tumor progression.

## Abstract

Synovial sarcoma is a rare soft tissue malignancy that is most commonly found in the extremities of adolescents and young adults. Despite accounting for a small percentage of all soft tissue sarcomas, its aggressive behaviour makes early recognition and management crucial. We present the rare case of a 64-year-old man with a large epigastric mass extending into the mediastinum and involving the pericardium, which was found to be a synovial sarcoma arising from the falciform ligament. The tumour was locally invading the liver and anterior mediastinum and was associated with pulmonary metastases. Despite treatment with neoadjuvant chemotherapy, the tumour demonstrated only a partial response at the primary site and progression of metastatic disease, precluding surgical resection.

## Linked entities

- **Diseases:** synovial sarcoma (MONDO:0010434)

## Full-text entities

- **Diseases:** Synovial Sarcoma (MESH:D013584), pulmonary metastases (MESH:D009362), malignancy (MESH:D009369), soft tissue sarcomas (MESH:D012509)

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12813936/full.md

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Source: https://tomesphere.com/paper/PMC12813936