Albiflorin‐Mediated MAP2K1 Targeting and HIF‐1 Signaling Inhibition Contribute to the Therapeutic Efficacy in Hyperuricemia‐Associated Cognitive Impairment
Huimin Xiao, Xinwen Huang, Rui Yao, Jincai Liu, Linrui Duan, Siwang Wang, Jinming Gao
TL;DR
This study shows that albiflorin, a compound from Paeonia suffruticosa, helps treat cognitive issues linked to high uric acid by targeting specific brain pathways.
Contribution
The study identifies albiflorin's role in targeting MAP2K1 and inhibiting HIF-1 signaling to treat hyperuricemia-associated cognitive impairment.
Findings
Albiflorin improves cognitive function and reduces hippocampal damage in HUA-CI mice.
Albiflorin inhibits HIF-1 signaling, reducing inflammation and neuronal apoptosis.
Network pharmacology confirms strong binding between albiflorin and MAP2K1.
Abstract
This study investigated the therapeutic effects and mechanisms of Paeonia suffruticosa fruit pod extract (EMP) and its main component albiflorin (AF) on hyperuricemia‐associated cognitive impairment (HUA‐CI). A HUA‐CI mouse model was established, with cognitive function evaluated via Morris water maze. Hippocampal pathology, inflammation, oxidative stress, and apoptosis were assessed using HE staining, ELISA, TUNEL, and Western blotting. Network pharmacology predicted EMP’s targets, and molecular docking analyzed AF‐MAP2K1 binding. In vitro experiments used UA‐stimulated BV2 and HT22 cells to explore AF’s effect on HIF‐1 signaling. EMP significantly improved cognitive function and reduced pathological damage in the hippocampus of HUA‐CI mice. It exerted protective effects by inhibiting inflammatory responses, alleviating oxidative stress, and preventing cell apoptosis. Network…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11
Figure 12
Figure 13
Figure 14
Figure 15
Figure 16
Figure 17
Figure 18
Figure 19
Figure 20
Figure 21
Figure 22
Figure 23
Figure 24
Figure 25
Figure 26
Figure 27
Figure 28
Figure 29
Figure 30
Figure 31
Figure 32
Figure 33
Figure 34
Figure 35
Figure 36
Figure 37
Figure 38
Figure 39
Figure 40
Figure 41
Figure 42
Figure 43
Figure 44
Figure 45
Figure 46
Figure 47Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsGout, Hyperuricemia, Uric Acid · Traditional Chinese Medicine Analysis · Magnolia and Illicium research