# Spatially fractionated radiation therapy for treating recurrent glioblastoma: a dosimetric feasibility study

## TL;DR

This study shows that spatially fractionated radiation therapy is a feasible treatment option for recurrent glioblastoma, but it may increase the risk of brain tissue damage.

## Contribution

The study evaluates the dosimetric feasibility of SFRT for recurrent glioblastoma using two planning techniques.

## Key findings

- SFRT plans for recurrent GBM were dosimetrically acceptable with controlled doses to critical organs.
- The SCART technique resulted in a higher VTV-to-GTV ratio compared to the LRT technique.
- SFRT increased V120Gy to the brain, potentially raising the risk of radiation-induced necrosis.

## Abstract

Spatially fractionated radiation therapy (SFRT) shows promise for treating bulky, advanced, or recurrent tumors. To evaluate the feasibility of SFRT for patients with recurrent glioblastoma (GBM), we conducted a planning study involving 14 patients, analyzing vertex target volume (VTV) contours and cumulative doses to both targets and organs at risk (OARs).

The patients were divided into two groups based on gross tumor volume (GTV): 10 patients with GTV > 15 cc; 4 patients with GTV ≤ 15 cc. SFRT was planned as an upfront boost, using LATTICE radiotherapy (LRT) and stereotactic central ablative radiation therapy (SCART) respectively. With a LRT technique, vertex diameters ranged from 0.8–1.5 cm, with center-to-center spacing of 2–4 cm.

GTV geometry—not size—determined mean vertex diameter (MVD: 0.99 ± 0.12 cm), spacing (2.93 ± 0.34 cm), and the VTV-to-GTV ratio (VGR: 6.6 ± 1.7%). With a SCART technique, the mean VGR was 25.8 ± 10.0%. Compared with the original sum plan, the cumulative EQD22 dose in the SFRT sum plan to critical OARs was well-controlled, such as the brainstem with a difference of 0.36 ± 1.00%. However, V120Gy to the brain in the SFRT sum plan increased by 4.51 ± 3.97 cc, for the 12 patients with an original V120Gy < 2 cc. Increased V120Gy to the brain might elevate the risk of radiation-induced necrosis.

In summary, our planning study demonstrates that dosimetrically acceptable SFRT plans can be achieved for recurrent GBM. The main clinical consideration is balancing the potential benefit of SFRT against the risk of radiation-induced necrosis.