Emergence of a novel genotype of extensively drug-resistant Shigella sonnei carrying blaDHA-1 in diverse patient populations, Los Angeles, 2024–2025
Shekina Gonzalez-Ferrer, Bennett Shaw, Lilian Fung, Raphael J. Landovitz, Daniel Z. Uslan, Shangxin Yang
TL;DR
A new drug-resistant strain of Shigella sonnei with the blaDHA-1 gene was found in unrelated patients, suggesting community spread.
Contribution
Identification of a novel XDR Shigella sonnei genotype with blaDHA-1 in diverse patients and evidence of community transmission.
Findings
A novel XDR S. sonnei strain carrying blaDHA-1 was identified in two unrelated cases.
Whole-genome sequencing showed close genetic relatedness, indicating potential community spread.
The transmission route of this XDR strain remains unknown.
Abstract
Extensively drug-resistant (XDR) Shigella is a public health threat, historically linked to blaCTX-M-15 gene in sexually transmitted cases. We describe a novel XDR S. sonnei carrying an AmpC-type blaDHA-1 gene from two unrelated cases with unknown transmission route; whole-genome sequencing revealed close genetic relatedness, signaling broader community spread.
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Taxonomy
TopicsEscherichia coli research studies · Antibiotic Resistance in Bacteria · Viral gastroenteritis research and epidemiology