NIR imaging-guided carbon monoxide nanomedicine: Design strategies, stimuli-responsive release, and multimodal synergistic therapies for precision disease treatment
Yaoqiang Li, Yeneng Dai, Bo Wang, Nan Zhang, Kangyi Yan, Haoqin Chen, Hongrong Shi, Hongli Chen, Qingzhi Wang, Jierui Yan, Xiaobo Wang, Peiyang Gao, Gongcheng Ma, Ya Hou, Qihang Ding, Qi Zhao
TL;DR
This paper reviews how near-infrared imaging helps control carbon monoxide delivery for precise disease treatment, combining imaging with therapy to improve effectiveness and safety.
Contribution
The paper provides a comprehensive review of NIR-II-guided CO nanomedicine design and therapies, emphasizing multimodal synergies and clinical translation challenges.
Findings
NIR-II imaging enables precise CO delivery with high resolution and deep tissue penetration.
CO nanomedicine combined with photothermal and immunotherapy shows enhanced therapeutic efficacy.
Challenges include subcellular CO monitoring and synergy between imaging and CO bioactivity.
Abstract
Endogenous gaseous molecules, especially carbon monoxide (CO), exhibit unique therapeutic potential in regulating cancer, infections, and inflammation owing to their dose-dependent bioactivity and multi-faceted mechanisms. However, challenges in spatiotemporal control and real-time monitoring of CO delivery hinder clinical translation. The integration of near-infrared II (NIR-II) imaging with CO nanodelivery systems provides a promising avenue for precise visualization and controlled gas therapy, offering deep tissue penetration, high resolution, and a favorable signal-to-noise ratio for guided therapy. This review systematically summarizes recent advances in NIR-II-guided CO nanoplatforms, focusing on design strategies, including polymers, core-shell structures, Metal-Organic Frameworks (MOFs), and peptide-modified systems, as well as their stimulus-responsive mechanisms across…
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Taxonomy
TopicsNanoplatforms for cancer theranostics · Heme Oxygenase-1 and Carbon Monoxide · Advanced Nanomaterials in Catalysis