# The effect of high lateral position on antibiotic exposure duration in patients with severe traumatic brain injury: a retrospective observational cohort study

## TL;DR

This study found that placing severe traumatic brain injury patients in a high lateral position may reduce the duration of antibiotic use.

## Contribution

The study explores the novel association between high lateral positioning and reduced antibiotic exposure in patients with severe traumatic brain injury.

## Key findings

- HLP was independently associated with a shorter duration of antibiotic use.
- Patients in the HLP group had trends toward fewer days of mechanical ventilation and lower tracheostomy rates.
- COPD was associated with a longer duration of antibiotic use.

## Abstract

Patients with severe traumatic brain injury (sTBI) often require mechanical ventilation and have a high incidence of aspiration pneumonia, leading to prolonged antibiotic exposure. This study assesses the association between high lateral position (HLP) and antibiotic exposure duration in sTBI patients, and reports on safety and feasibility.

This study retrospectively collected data from 138 patients with severe traumatic brain injury complicated by aspiration pneumonia who were treated in the intensive care unit from January 2023 to June 2024. Patients were divided into two groups based on whether they received high lateral position (HLP) therapy: the HLP group (n = 45) and the non-HLP group (n = 93). Univariate and multivariate linear regression analyses were used to identify independent risk factors associated with the duration of antibiotic use, and the association between HLP therapy and antibiotic use duration was evaluated by comparing the two groups.

Patients who received HLP had a shorter duration of antibiotic use; both univariate and multivariate regression analyses suggested an association between HLP and shorter duration of use. Univariate linear regression analysis showed that HLP, chronic obstructive pulmonary disease (COPD), arterial oxygen partial pressure, and oxygenation index were all associated with the duration of antibiotic use. Multivariate linear regression analysis further confirmed that HLP was independently associated with a shorter duration of antibiotic use (β = −2.58; 95% CI, −4.44 to −0.71; p = 0.008), while COPD was associated with a longer duration of use (β = 8.78; 95% CI, 4.42 to 13.13; p < 0.001).

In this retrospective cohort, HLP was associated with a shorter duration of antibiotic exposure and showed trends toward fewer days of mechanical ventilation and a lower tracheostomy rate. Given the nonrandomized design and potential residual confounding, these findings are exploratory and should be confirmed in prospective randomized studies.