Programmable ROS modulation by nanomedicine for rheumatoid arthritis treatment
Guojun Pan, Yaxin Zhang, Di Liu, Yongbin Wang, Hengzhen Zhang, Haoen Pan, Qingfan Hou, Xiangrui Kong, Fujin Lv, Na Xiao, Renshuai Zhang
TL;DR
This paper reviews how nanomedicine can precisely modulate reactive oxygen species to treat rheumatoid arthritis, offering new therapeutic strategies.
Contribution
The paper systematically categorizes and evaluates ROS-modulating nanotherapeutic systems for rheumatoid arthritis.
Findings
ROS-centered nanotherapies can reshape the immune microenvironment and restore redox balance in RA.
Different nanosystems, including ROS-scavenging and responsive types, offer advantages in RA treatment.
Challenges remain in biosafety, controllability, and clinical translation of these nanotherapies.
Abstract
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint destruction. Extensive studies have demonstrated that reactive oxygen species (ROS) play a critical role in the pathogenesis and progression of RA. Imbalanced ROS not only aggravate synovial inflammation and cartilage degradation but also disrupt immune homeostasis. In recent years, nanotechnology-based strategies for regulating ROS have provided new insights into the precise treatment of RA. This review systematically summarizes ROS-centered nanotherapeutic systems applied in RA therapy, including ROS-scavenging nanosystems, ROS-responsive nanosystems, ROS-scavenging and responsive composite nanosystems, and ROS-augmenting nanosystems. Furthermore, the review highlights the advantages of ROS-modulating nanosystems in reshaping the immune microenvironment,…
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Taxonomy
TopicsRheumatoid Arthritis Research and Therapies · Nanoplatforms for cancer theranostics · Spondyloarthritis Studies and Treatments