# Future prospects for image-derived input function in molecular imaging quantification with the 7 T MR-BrainPET insert

**Authors:** Cláudia Régio Brambilla, Julia Hilgers, Usman Khalid, Ninea Anasovi, Tornike Kikacheishvili, Jörg Mauler, Chang-Hoon Choi, Jürgen J. Scheins, N. Jon Shah, Christoph W. Lerche

PMC · DOI: 10.3389/fnins.2025.1725728 · Frontiers in Neuroscience · 2026-01-05

## TL;DR

A new 7T MR-BrainPET system combines PET and MRI to improve brain imaging accuracy and enable better disease understanding.

## Contribution

The paper highlights advancements in image-derived input function (IDIF) using a novel 7T MR-BrainPET insert for molecular imaging.

## Key findings

- The 7T MR-BrainPET insert enables molecular imaging quantification beyond current limits.
- PET/MR synergies are crucial for improving the accuracy of image-derived input functions.
- Promising applications and future challenges in molecular imaging are discussed.

## Abstract

Positron emission tomography (PET) and magnetic resonance imaging (MRI) offer complementary information about the human brain in health and disease. The simultaneous 7 T MR-BrainPET insert enables molecular imaging quantification beyond the current limits. Here we present the current status of the field highlighting PET/MR synergies for the image-derived input function (IDIF). We also discuss promising applications that will benefit from these advancements, as well the challenges to be addressed in the near future.

## Full-text entities

- **Chemicals:** BrainPET (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

93 references — full list in the complete paper: https://tomesphere.com/paper/PMC12813035/full.md

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Source: https://tomesphere.com/paper/PMC12813035