# Enigmatic presentation of glomus tumour of the tongue: diagnostic insights

**Authors:** Nairica Eurico Rebello, Anita Spadigam, Anita Dhupar, Jochima Cota, Vikas Dhupar

PMC · DOI: 10.3332/ecancer.2025.2006 · ecancermedicalscience · 2025-10-06

## TL;DR

A rare glomus tumour was found on a patient's tongue, highlighting the need for thorough diagnosis in unusual cases.

## Contribution

This case report presents a rare occurrence of glomus tumour in the oral cavity.

## Key findings

- The tumour was diagnosed through histopathology and immunohistochemistry.
- The oral cavity is an unusual site for glomus tumours.
- Comprehensive diagnostic work-up is crucial for rare tumours in the head and neck region.

## Abstract

Glomus tumour is a soft tissue neoplasm that is associated with the subungual region owing to the presence of the glomus body. A 53-year-old female patient was referred to the Department of Oral and Maxillofacial Pathology with the chief complaint of a swelling on the tongue of 3 months' duration. An ultrasound of the tongue suggested a vascular malformation. Histopathology revealed a well-defined proliferation of cells around blood vessels, surrounded by muscle and collagen fibres. A majority of the cells were clear with distinct nuclei. Some cells had an eosinophilic granular cytoplasm. Histopathology was augmented with immunohistochemistry to arrive at a diagnosis of glomus tumour of the tongue. The oral cavity is an unusual site for the occurrence of glomus tumour. This case emphasises the importance of a comprehensive diagnostic work-up in the diagnosis of swellings in the head and neck region, particularly in the context of rare tumours arising from cells that are not native to this site.

## Linked entities

- **Diseases:** glomus tumour (MONDO:0021064)

## Full-text entities

- **Diseases:** vascular malformation (MESH:D054079), swelling on the tongue (MESH:D014060), swellings (MESH:D004487), glomus tumour of the tongue (MESH:D014062), Glomus tumour (MESH:D005918), neoplasm (MESH:D009369)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12812824/full.md

## References

28 references — full list in the complete paper: https://tomesphere.com/paper/PMC12812824/full.md

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Source: https://tomesphere.com/paper/PMC12812824