# Wolf’s isotopic response of eczema after herpes zoster infection: case report and literature review

## TL;DR

This paper reports a case of eczema developing at the site of a healed herpes zoster infection, suggesting a possible link between the two conditions.

## Contribution

The novelty lies in presenting a new case of Wolf’s isotopic response with eczema and successful treatment with glucocorticoids.

## Key findings

- Eczema developed at the site of a previously healed herpes zoster infection.
- Systemic oral glucocorticoids led to significant improvement in skin lesions.
- No recurrence was observed during a 3-month follow-up.

## Abstract

Wolf’s post-herpetic isotopic response (PHIR) refers to the development of new cutaneous conditions, such as tumors, infections, or immune-mediated diseases, at the site of a previously healed herpetic eruption. The exact pathogenesis of Wolf’s PHIR remains incompletely understood. Four hypotheses have been proposed regarding the mechanism of postherpetic inflammatory isomorphic reactions: viral, immunological, vascular, and neurological. In this case, we show that a patient with eczema developed it at the original site following the resolution of the herpes zoster infection. After 2 weeks of systemic oral glucocorticoid treatment, the skin lesions improved significantly, and there was no recurrence during the 3-month follow-up.