# Diffuse large B-cell lymphoma with intussusception in adults: a case report and literature review

## TL;DR

A rare case of adult intussusception caused by diffuse large B-cell lymphoma is reported, highlighting the importance of early diagnosis and treatment.

## Contribution

This case report adds to the limited literature on adult intussusception caused by gastrointestinal lymphoma.

## Key findings

- Intussusception in adults may be caused by diffuse large B-cell lymphoma.
- Surgical treatment and postoperative chemotherapy improved the patient's prognosis.
- Early diagnosis is critical for better outcomes in such rare cases.

## Abstract

Intussusception secondary to gastrointestinal diffuse large B-cell lymphoma (DLBCL) is exceedingly rare in adults. We present a case of a 23-year-old male admitted with abdominal pain as the primary symptom. Computed tomography (CT) revealed an ileocolic intussusception involving the ascending and transverse colon, demonstrating a characteristic “target.” Conservative treatment (including air enema) was ineffective, and the patient finally received surgical treatment. The resected lesion was pathologically confirmed as DLBCL. The patient received postoperative chemotherapy with the R-CHOP regimen. At the 5-month follow-up, no complications or evidence of lymph node involvement elsewhere was observed. Adult intussusception patients should be highly alert to the possibility of malignant tumors, especially lymphoma. Early diagnosis and standardized comprehensive treatment are critical for improving long-term prognosis.