# Wetware network-based AI: a chemical approach to embodied cognition for robotics and artificial intelligence

**Authors:** Luisa Damiano, Antonio Fleres, Andrea Roli, Pasquale Stano

PMC · DOI: 10.3389/frobt.2025.1694338 · Frontiers in Robotics and AI · 2026-01-05

## TL;DR

This paper proposes a new AI approach using chemical networks to create embodied cognition in robotics, expanding beyond traditional silicon-based systems.

## Contribution

It introduces Wetware Network-Based AI (WNAI), a novel framework for cognition based on synthetic chemical self-organization.

## Key findings

- WNAI integrates network cybernetics and autopoietic theory to frame cognition as a material process.
- It complements embodied AI and neural networks by exploring synthetic domains for artificial cognition.
- The approach suggests implementing chemical neural networks for adaptive robotic intelligence.

## Abstract

Wetware Network-Based Artificial Intelligence (WNAI) introduces a new approach to robotic cognition and artificial intelligence: autonomous cognitive agents built from synthetic chemical networks. Rooted in Wetware Neuromorphic Engineering, WNAI shifts the focus of this emerging field from disembodied computation and biological mimicry to reticular chemical self-organization as a substrate for cognition. At the theoretical level, WNAI integrates insights from network cybernetics, autopoietic theory and enaction to frame cognition as a materially grounded, emergent phenomenon. At the heuristic level, WNAI defines its role as complementary to existing leading approaches. On the one hand, it complements embodied AI and xenobotics by expanding the design space of artificial embodied cognition into fully synthetic domains. On the other hand, it engages in mutual exchange with neural network architectures, advancing cross-substrate principles of network-based cognition. At the technological level, WNAI offers a roadmap for implementing chemical neural networks and protocellular agents, with potential applications in robotic systems requiring minimal, adaptive, and substrate-sensitive intelligence. By situating wetware neuromorphic engineering within the broader landscape of robotics and AI, this article outlines a programmatic framework that highlights its potential to expand artificial cognition beyond silicon and biohybrid systems.

## Full-text entities

- **Chemicals:** silicon (MESH:D012825)

## Full text

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## Figures

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## References

120 references — full list in the complete paper: https://tomesphere.com/paper/PMC12812610/full.md

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Source: https://tomesphere.com/paper/PMC12812610