# Effect of type 2 diabetes mellitus on sperm quality and outcomes of assisted reproductive techniques in infertile male patients

## TL;DR

This study finds that type 2 diabetes in men reduces sperm quality but does not affect the success of fertility treatments like IVF or ICSI.

## Contribution

The novel contribution is demonstrating that reduced sperm quality in men with type 2 diabetes does not impair ART outcomes.

## Key findings

- Men with T2DM had lower sperm volume and motility compared to non-diabetic controls.
- ART outcomes like implantation and pregnancy rates were similar between T2DM and non-diabetic groups.
- Sperm quality decline in T2DM did not lead to worse clinical pregnancy or embryo development outcomes.

## Abstract

Diabetes mellitus (DM) is one of the most common endocrine disorders affecting various physiological systems and tissues, including the reproductive organs in men. However, the consequences of DM for male individuals undergoing assisted reproductive technology (ART) remain unclear.

To investigate the sperm quality and the outcomes of in vitro fertilization - embryo transfer (IVF-ET) and intracytoplasmic sperm injection - embryo transfer (ICSI-ET) in patients with type 2 diabetes mellitus (T2DM).

We retrospectively analyzed data from 318 infertile couples for IVF/ICSI cycle outcomes. The experimental group included 106 infertile couples (with male partners all diagnosed with T2DM) who underwent ART treatment at our center. The negative control group consisted of 212 non-diabetic infertile couples, matched by male/female body mass index (BMI) (± 1 kg/m²), male/female age (± 2 years), and serum anti-Müllerian hormone (AMH) levels (± 2 ng/mL). Patients were categorized into two groups based on clinical pregnancy. The χ² test and logistic regression analysis were used to identify and determine the influencing factors of clinical pregnancy.

Infertile men with T2DM had significantly lower sperm volume (2.4 ± 2.2 vs. 2.7 ± 1.2, P < 0.01) and significantly decreased sperm motility compared to the control group (23.0 ± 17.2 vs. 29.7 ± 15.3, P < 0.01). In IVF/ICSI cycles, both groups exhibited similar results in two-pronuclear (2PN) fertilization rates and high-grade embryo rates (p > 0.05). The implantation rate, clinical pregnancy rate, and miscarriage rate also showed no significant differences (p > 0.05).

T2DM in infertile men exerts adverse effects on sperm quality; however, the decline in sperm quality did not translate into compromised clinical ART outcomes.