# Functional pancreatic neuroendocrine tumors predominantly presenting with hypercalcemia: a case report

## TL;DR

This case report describes a rare pancreatic tumor causing severe hypercalcemia over 10 years and highlights insights for diagnosis and treatment.

## Contribution

The report provides a detailed clinical account of a rare PNET causing hypercalcemia through PTHrP secretion.

## Key findings

- The patient experienced recurrent life-threatening hypercalcemia over a decade due to a PNET secreting PTHrP.
- The case offers insights into the management and evolution of hypercalcemia caused by functional PNETs.
- Such tumors are extremely rare and require careful clinical attention for diagnosis and treatment.

## Abstract

Functional pancreatic neuroendocrine tumors (F-PNETs) that secrete parathyroid hormone-related protein (PTHrP) and cause hypercalcemia are extremely rare. This report details a 10-year course of a patient with pancreatic neuroendocrine tumor (PNET) and recurrent life-threatening hypercalcemia. Moreover, it comprehensively describes the evolution and management of hypercalcemia in this case, aiming to offer valuable insights for clinical diagnosis and treatment.