# Editorial: Cellular contributors and consequences of protein misfolding and aggregation

**Authors:** Anoop Arunagiri, Emily Sontag, Verena Kohler, Arunkumar Venkatesan

PMC · DOI: 10.3389/fmolb.2025.1759495 · Frontiers in Molecular Biosciences · 2026-01-05

## Full-text entities

- **Genes:** ERN1 (endoplasmic reticulum to nucleus signaling 1) [NCBI Gene 2081] {aka IRE1, IRE1P, IRE1a, hIRE1p}, GBA1 (glucosylceramidase beta 1) [NCBI Gene 2629] {aka GBA, GCB, GLUC}, CGB5 (chorionic gonadotropin subunit beta 5) [NCBI Gene 93659] {aka CGB, HCG}, OPTN (optineurin) [NCBI Gene 10133] {aka ALS12, FIP2, GLC1E, HIP7, HYPL, NRP}, EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3) [NCBI Gene 9451] {aka PEK, PERK, WRS}, SOD1 (superoxide dismutase 1) [NCBI Gene 6647] {aka ALS, ALS1, HEL-S-44, IPOA, SOD, STAHP}, ATF6 (activating transcription factor 6) [NCBI Gene 22926] {aka ACHM7, ATF6A, ATP6alpha}, IAPP (islet amyloid polypeptide) [NCBI Gene 3375] {aka DAP, IAP}, INS (insulin) [NCBI Gene 3630] {aka IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10}, SNCA (synuclein alpha) [NCBI Gene 6622] {aka NACP, PARK1, PARK4, PD1}, LDLR (low density lipoprotein receptor) [NCBI Gene 3949] {aka LDLCQ2}, APOE (apolipoprotein E) [NCBI Gene 348] {aka AD2, APO-E, ApoE4, LDLCQ5, LPG}, TARDBP (TAR DNA binding protein) [NCBI Gene 23435] {aka ALS10, TDP-43}, MYOC (myocilin) [NCBI Gene 4653] {aka GLC1A, GPOA, JOAG, JOAG1, TIGR}, HTT (huntingtin) [NCBI Gene 3064] {aka HD, IT15, LOMARS}, NOTCH3 (notch receptor 3) [NCBI Gene 4854] {aka CADASIL, CADASIL1, CARASIL1, CASIL, FPLD1, IMF2}, MAPT (microtubule associated protein tau) [NCBI Gene 4137] {aka DDPAC, FTD1, FTDP-17, MAPTL, MSTD, MTBT1}
- **Diseases:** mitochondrial dysfunction (MESH:D028361), PD (MESH:D010300), neurodegenerative diseases (MESH:D019636), ALS (MESH:D000690), toxicity (MESH:D064420), DLB (MESH:D020961), synucleinopathies (MESH:D000080874), proteinopathies (MESH:D057165), CADASIL (MESH:D046589), diabetes (MESH:D003920), HD (MESH:D006816), glaucoma (MESH:D005901), type 2 diabetes (MESH:D003924), MSA (MESH:C537381), inherited diseases (MESH:D030342)
- **Chemicals:** QBP1 (-), lipid (MESH:D008055), ebselen (MESH:C042986), thioflavin T (MESH:C009462), polyP (MESH:D011122)
- **Species:** Sida cordifolia (species) [taxon 108362]

## Full text

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Source: https://tomesphere.com/paper/PMC12812553