# IgG4-Related Disease: Endocrine Involvement, Clinical Implications, and Management Strategies

## TL;DR

This paper reviews how IgG4-related disease affects the endocrine system, focusing on diagnosis and treatment strategies to prevent gland damage.

## Contribution

The paper provides a focused review on underdiagnosed endocrinological manifestations of IgG4-related disease and emphasizes clinical awareness.

## Key findings

- Thyroid and pituitary glands are most commonly affected endocrinological organs in IgG4-related disease.
- Early diagnosis using serological, radiological, and histopathological findings is crucial to prevent irreversible damage.
- Corticosteroids are the primary treatment, with immunosuppressive agents used for severe cases.

## Abstract

IgG4-related disease is a systemic fibroinflammatory disorder characterized by its tumefactive lesions, elevated serum IgG4 levels, and unique histological findings such as lymphoplasmacytic infiltrates in a storiform pattern. It affects a wide variety of organ systems however, endocrinological manifestations remain uncommon and underdiagnosed due to nonspecific presentations. The thyroid and pituitary glands are the most commonly affected endocrinological organs, with the thyroid presenting as Riedel’s thyroiditis or IgG4-related thyroiditis, and the pituitary involvement as hypophysitis. Symptoms could arise either due to direct organ infiltration or a decrease in hormone production and release. Diagnosing IgG4-related disease depends on serological, radiological, and histopathological findings. While immunosuppressive and biological agents are used for more severe or refractory cases, corticosteroids are the mainstay of treatment considering the autoimmune etiology of this disease. Early recognition of endocrinological involvement in IgG4-related disease is imperative for treating and preventing eventual irreversible glandular damage, highlighting the need for increased clinical awareness and multidisciplinary approaches amongst physicians. This review focuses on the endocrinological manifestations, clinical implications, and management strategies of IgG4-related disease.