# Editorial: Overcoming resistance in DDR inhibition: new targets and therapeutic strategies **Authors:** Chi-Lin Tsai, Ana Cristina Gonçalves, Zamal Ahmed PMC · DOI: 10.3389/fmolb.2025.1766744 · Frontiers in Molecular Biosciences · 2026-01-05 ## Full-text entities - **Genes:** POLD3 (DNA polymerase delta 3, accessory subunit) [NCBI Gene 10714] {aka IMD122, P66, P68, PPP1R128}, RECQL4 (RecQ like helicase 4) [NCBI Gene 9401] {aka RECQ4}, H2AX (H2A.X variant histone) [NCBI Gene 3014] {aka H2A.X, H2A/X, H2AFX}, PIP (prolactin induced protein) [NCBI Gene 5304] {aka BRST-2, GCDFP-15, GCDFP15, GPIP4}, MAD2L2 (mitotic arrest deficient 2 like 2) [NCBI Gene 10459] {aka FANCV, MAD2B, POLZ2, REV7}, TP53BP1 (tumor protein p53 binding protein 1) [NCBI Gene 7158] {aka 53BP1, TDRD30, p202, p53BP1}, FEN1 (flap structure-specific endonuclease 1) [NCBI Gene 2237] {aka FEN-1, MF1, RAD2}, SPATA2 (spermatogenesis associated 2) [NCBI Gene 9825] {aka PD1, PPP1R145, tamo}, PARP1 (poly(ADP-ribose) polymerase 1) [NCBI Gene 142] {aka ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1}, BRCA1 (BRCA1 DNA repair associated) [NCBI Gene 672] {aka BRCAI, BRCC1, BROVCA1, FANCS, IRIS, PNCA4}, GTF2H5 (general transcription factor IIH subunit 5) [NCBI Gene 404672] {aka C6orf175, TFB5, TFIIH, TGF2H5, TTD, TTD-A}, BRCA2 (BRCA2 DNA repair associated) [NCBI Gene 675] {aka BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD}, CD274 (CD274 molecule) [NCBI Gene 29126] {aka ADMIO5, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1}, PCNA (proliferating cell nuclear antigen) [NCBI Gene 5111] {aka ATLD2} - **Diseases:** toxicity (MESH:D064420), cancer (MESH:D009369), DDR deficiencies (MESH:D049914), inflammation (MESH:D007249), ovarian, breast, and pancreatic cancers (MESH:D010051), breast cancer (MESH:D001943) - **Chemicals:** olaparib (MESH:C531550) - **Species:** Homo sapiens (human, species) [taxon 9606], Thermochaetoides thermophila (species) [taxon 209285] ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12812393/full.md ## References 5 references — full list in the complete paper: https://tomesphere.com/paper/PMC12812393/full.md --- Source: https://tomesphere.com/paper/PMC12812393