# Synovial Lipomatosis of the Knee: A Case Report and Review of the Literature

**Authors:** El Kacem El Marbouh, Abderrahim Majjad, Said Akjouj, Mohammed Boussaidane, Abderrahim El Ktaibi, Oumaima Mekhakh, Hamza Toufik, Leila Taoubane, Ahmed Bezza

PMC · DOI: 10.7759/cureus.99587 · Cureus · 2025-12-18

## TL;DR

A case report describes synovial lipomatosis of the knee, a rare benign condition, and highlights the importance of early diagnosis and treatment for effective recovery.

## Contribution

This paper adds a new clinical case of synovial lipomatosis and reinforces the diagnostic and therapeutic role of MRI and arthroscopic synovectomy.

## Key findings

- MRI accurately identified synovial lipomatosis with frond-like synovial projections and fat-signal intensity.
- Arthroscopic synovectomy resolved symptoms and prevented recurrence in a 34-year-old patient.
- Early diagnosis and treatment are crucial to prevent joint dysfunction and degenerative changes.

## Abstract

Synovial lipomatosis (lipoma arborescens) is a rare, benign, intra-articular lesion characterized by villous proliferation of mature adipocytes, most commonly affecting the knee. Early recognition is essential to prevent misdiagnosis and long-term joint dysfunction. MRI is highly suggestive, while histopathology confirms the diagnosis. We describe the case of a 34-year-old male with persistent left knee monoarthritis. Laboratory investigations, including complete blood count, erythrocyte sedimentation rate, and C-reactive protein, were within normal limits. MRI showed frond-like synovial projections with fat-signal intensity suppressed on fat-saturated sequences. Histopathology confirmed the diagnosis of synovial lipomatosis. The patient underwent synovectomy, resulting in full resolution of symptoms and no recurrence during four months of follow-up. Synovial lipomatosis should be considered in patients with chronic knee effusion. MRI is usually diagnostic, and early arthroscopic synovectomy restores function, prevents degenerative changes, and achieves excellent outcomes.

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** intra-articular lesion (MESH:D057072), joint dysfunction (MESH:D007592), chronic knee effusion (MESH:C564895), lipoma arborescens (MESH:D008067), Synovial Lipomatosis (MESH:D013581)
- **Chemicals:** fat (MESH:D005223)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC12812210/full.md

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Source: https://tomesphere.com/paper/PMC12812210