# Cancer Risk and Mortality Following Kaposi Sarcoma Among People with HIV in the United States, 2000 to 2019

## TL;DR

People with HIV who develop Kaposi sarcoma face higher cancer risks and mortality, but survival improved over time in the U.S.

## Contribution

The study quantifies elevated cancer risk and reduced mortality after Kaposi sarcoma in people with HIV.

## Key findings

- PWH with Kaposi sarcoma had a 2.8-fold higher cancer risk than those without it.
- Mortality after Kaposi sarcoma decreased significantly between 2000–2002 and 2012–2015.

## Abstract

People with HIV (PWH) have increased Kaposi sarcoma (KS) risk. Among 2,645 PWH with KS in the United States HIV/AIDS Cancer Match Study, subsequent cancer risk was elevated 2.8-fold (95% confidence interval [CI]: 2.4–3.3) compared to PWH without KS. Mortality after KS declined 2000–2002 and 2012–2015 (hazard ratio = 0.64; 95%CI: 0.55–0.74).

The online version contains supplementary material available at 10.1007/s10552-025-02105-0.