Clear Cell Myoepithelial Carcinoma of the Clavicle: A Case Report

TL;DR

A rare case of clear cell myoepithelial carcinoma in the clavicle was diagnosed after initial misidentification as chondrosarcoma.

Contribution

This case report adds to the limited literature on clear cell myoepithelial carcinoma involving the clavicle.

Findings

Clear cell myoepithelial carcinoma was confirmed via histopathology after initial misdiagnosis as chondrosarcoma.

The patient underwent successful en bloc resection and reconstruction with a fibular autograft.

The case emphasizes the need for thorough histopathologic evaluation in rare bone tumors.

Abstract

Clear cell myoepithelial carcinoma involving the clavicle is an exceptionally rare malignancy. Its nonspecific clinical and radiologic features pose significant diagnostic challenges, often mimicking more common primary bone tumors such as chondrosarcoma and osteosarcoma. We report the case of a 53-year-old male with a slowly enlarging, painless supraclavicular mass present for nearly a decade. Imaging studies suggested chondrosarcoma, and an initial fine-needle biopsy yielded a diagnosis of grade II chondrosarcoma. Staging showed no metastatic disease, and the patient underwent en bloc resection of the tumor with the affected clavicular segment, followed by reconstruction using a fibular autograft fixed with dual plating. Final histopathology and a comprehensive immunohistochemical panel confirmed the diagnosis of clear cell myoepithelial carcinoma. All margins were negative, and postoperative recovery was uneventful. This case highlights the diagnostic complexity of rare clavicular tumors and underscores the importance of thorough histopathologic evaluation, as imaging and needle biopsy may occasionally provide misleading diagnoses in uncommon bone lesions. Wide surgical excision remains the cornerstone of treatment, and reconstruction should be individualized based on defect size and regional anatomical considerations. Continued reporting of such rare cases is essential to improve diagnostic accuracy and guide treatment strategies

Figures