Synergistic photothermal antibacterial efficacy and high biocompatibility of silver-carbon core-shell nanoparticles
Chunning Gu, Li Guo, Ziqian Zhou, Anyuan Shi, Lele Wu, Wei Cheng
TL;DR
Researchers developed silver-carbon core-shell nanoparticles that effectively kill bacteria with light while being safe for human cells.
Contribution
The study introduces Ag@C nanoparticles with high photothermal antibacterial efficacy and excellent biocompatibility.
Findings
Ag@C nanoparticles showed excellent photothermal conversion efficiency under 808 nm near-infrared irradiation.
Ag@C nanoparticles eradicated Methicillin-resistant Staphylococcus aureus (MRSA) with no significant cytotoxicity.
Hemolysis tests confirmed the high biocompatibility of Ag@C nanoparticles.
Abstract
Safe and effective antimicrobial treatment strategies are urgently required for the prevention and control of infectious diseases. While silver-based nanoparticles (AgNPs) are currently acknowledged as the most potent metal-based antibacterial agents, their potential cytotoxicity poses a significant barrier to further clinical applications. Herein, we synthesized carbonaceous coated silver nanocore (Ag@C) core-shell nanoparticles and investigated their material properties, biocompatibility, and antibacterial efficacy. The produced Ag@C exhibited a uniform core-shell structure with an overall diameter of 256.40 nm, a shell thickness of 92.20 nm, and a silver core diameter of 67.45 nm. Under irradiation with 808 nm near-infrared (NIR) irradiation, Ag@C demonstrated excellent photothermal conversion efficiency. The results from apoptosis detection via flow cytometry, CCK-8 cytotoxicity…
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Taxonomy
TopicsNanoplatforms for cancer theranostics · Graphene and Nanomaterials Applications · Gold and Silver Nanoparticles Synthesis and Applications