# Comparison of chemo-mechanical and conventional caries removal methods in 6-to-12-year-old children: Randomized clinical trial

**Authors:** Abdulrahman Bala Malami, Yewande Isabella Adeyemo, Aliyu Aminu, Folakemi Adenike Oredugba

PMC · DOI: 10.1371/journal.pone.0339771 · 2026-01-16

## TL;DR

This study compared two methods for removing tooth decay in children and found that while drilling is faster and more effective, a chemical method causes less anxiety and is better for patient comfort.

## Contribution

The study provides a direct comparison of chemo-mechanical and conventional drilling methods in children, focusing on effectiveness and patient behavior.

## Key findings

- Conventional drilling reduced bacterial load more effectively than the chemo-mechanical method.
- Chemo-mechanical removal took significantly longer than conventional drilling.
- Children showed more positive behavior during chemo-mechanical treatment compared to drilling.

## Abstract

To address the discomfort associated with conventional drilling for caries removal in children, a minimally invasive approach such as chemo-mechanical caries removal was developed. This study aimed to compare the effectiveness of, and patient behavior associated with chemo-mechanical caries removal versus conventional drilling in children aged 6–12 years.

A split-mouth randomized clinical trial was conducted involving 66 molar teeth. The effectiveness of Papacarie Duo Gel and conventional drilling methods was assessed using colony-forming unit (CFU) counts before and after each treatment. Cavity preparation time and intraoperative patient behavior using the Frankl Behavior Rating Scale were also evaluated.

Both methods resulted in a significant reduction in bacterial counts post-treatment. However, conventional drilling showed a greater percentage reduction in bacterial load (82.9 ± 13.9; t = −4.42, p < 0.001) compared to the chemo-mechanical method (68.6 ± 16.6). The mean caries removal time was 692.4 ± 245.9 sec with the chemo-mechanical method, compared to 266.9 ± 101.6 sec with conventional drilling. In terms of behavior, 57.6% of the children exhibited a positive response during chemo-mechanical treatment whereas negative behavior was more commonly observed with conventional drilling.

While conventional drilling remains the better-established and time-efficient method of caries removal, the chemo-mechanical technique serves as a valuable alternative for managing children, reducing anxiety and promoting greater comfort and cooperation during treatment.

PanAfrican Clinical Trial Registry PACTR202310877678533

## Full-text entities

- **Diseases:** caries (MESH:D003731), anxiety (MESH:D001007)
- **Chemicals:** Papacarie Duo Gel (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12810845/full.md

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Source: https://tomesphere.com/paper/PMC12810845