# Buccal mucosal graft urethroplasty in pan-urethral stricture in an adult patient with epidermolysis bullosa: a case report and review of literature

**Authors:** Huda Meshikhes, Dania Alseini, Hossam S El-Tholoth, Tala Al-Afraa

PMC · DOI: 10.1093/jscr/rjaf1082 · 2026-01-16

## TL;DR

A 34-year-old man with epidermolysis bullosa successfully underwent a buccal graft urethroplasty to treat a severe urethral stricture.

## Contribution

This case report presents a successful use of buccal mucosal graft in treating pan-urethral stricture in a patient with epidermolysis bullosa.

## Key findings

- Buccal mucosal graft urethroplasty was effective in treating pan-urethral stricture in a patient with epidermolysis bullosa.
- The procedure resulted in a successful outcome without complications.
- The case highlights the potential of buccal grafts in managing genitourinary complications in this rare disorder.

## Abstract

Epidermolysis bullosa is a rare genetic disorder that leads to skin fragility and the formation of blisters from the slightest trauma. There are 4 major types that have been described, with junctional and dystrophic types being more prone to result in genitourinary tract complications. The most common complication is meatal stenosis. Others include urethral stricture, urinary retention, ureteral stricture, bladder hypertrophy, and urinary tract infections. We report the successful outcome of urethroplasty using buccal graft mucosa for a 34-year-old male with epidermolysis bullosa who suffered from pan-urethral stricture.

## Linked entities

- **Diseases:** epidermolysis bullosa (MONDO:0006541), urethral stricture (MONDO:0002127)

## Full-text entities

- **Diseases:** blisters (MESH:D001768), genetic disorder (MESH:D030342), Epidermolysis bullosa (MESH:D004820), urinary tract infections (MESH:D014552), urinary retention (MESH:D016055), meatal stenosis (MESH:D003251), bladder hypertrophy (MESH:D006984), urethral stricture (MESH:D014525), trauma (MESH:D014947), skin fragility (MESH:C536183)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12810726/full.md

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Source: https://tomesphere.com/paper/PMC12810726