Leaf Ethanol Extract of Dimocarpus longan Lour. Ameliorates Type 2 Diabetes Mellitus in Rats by Regulating Metabolic Pathways and Gut Microbiota
Chunlian Lu, Piaoxue Zheng, Sisi Chen, Yanli Liang, Yuxin Jiang, Anqi Huo, Jingjing Xie, Jiawen Peng, Yuming Ma, Jiali Wei, Zhidong Ma, Hua Zhu, Jie Liang
TL;DR
This study shows that leaf extract from Dimocarpus longan Lour. may help treat type 2 diabetes in rats by affecting metabolism and gut bacteria.
Contribution
The study identifies specific metabolic pathways and gut microbiota changes linked to the anti-diabetic effects of D. longan leaf extract.
Findings
LYY altered 61 metabolites involved in key metabolic pathways like fatty acid and bile acid metabolism.
LYY increased beneficial gut bacteria like Ligilactobacillus and decreased harmful ones like Desulfobacterota.
These changes improved glucose tolerance and metabolic balance in diabetic rats.
Abstract
The leaves of Dimocarpus longan Lour. are used unilaterally as Chinese herbal medicines to treat diabetes in Chongzuo and Hezhou, Guangxi, but the mechanism of its treatment of diabetes is not yet clear, and further research is needed. This study examined the effects of leaf ethanol extract of D.s longan Lour. on metabolic pathways and gut microbiota in rats with type 2 diabetes mellitus (T2DM). The rats were randomly divided into four groups: HG + HFD (T2DM model, fed with high‐sugar and high‐fat diet), control (regular diet), MET (positive metformin), and LYY (leaf ethanol extract of D. longan Lour). Metabolite profiles and gut microbiota composition were analyzed using liquid chromatography_mass spectrometry and 16S rDNA sequencing. Metabolomics analysis revealed 61 distinct metabolites in the LYY group, such as Leu‐Pro and taurolithocholic acid 3‐sulfate, which influence valine,…
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Taxonomy
TopicsNatural Antidiabetic Agents Studies · Gut microbiota and health · Mangiferin and Mango Extracts