Biofilm Formation in Clinical Acinetobacter baumannii Is Influenced by Isolate Source and Is Inversely Correlated With Antibiotic Resistance
Qutaiba Ababneh, Dua’a Alawneh, Ziad Jaradat, Esra’a Al-Zoubi, Ali Atoom, Neda’a Aldaken, Ekhlas Al-Rousan, Yazeed Alshari, Ismail Saadoun
TL;DR
This study shows that Acinetobacter baumannii isolates from ICUs and those less resistant to antibiotics tend to form stronger biofilms, which could affect treatment decisions.
Contribution
The study reveals a novel inverse correlation between antibiotic resistance and biofilm formation in clinical A. baumannii isolates.
Findings
ICU isolates showed higher biofilm formation and greater antibiotic resistance compared to non-ICU isolates.
Susceptible isolates had a significantly higher tendency to form strong biofilms.
Biofilm formation varied by hospital and specimen type, with blood and cerebrospinal fluid isolates showing stronger biofilm formation.
Abstract
Acinetobacter baumannii is a troublesome bacterium that is highly prevalent in hospital settings, particularly in intensive care units (ICUs). Biofilm is one of the main virulence factors that makes A. baumannii a successful pathogen, enabling it to survive the harshest environments. This study aimed to corrolate the biofilm‐forming capacity of clinical A. baumannii isolates with their antibiotic resistance phenotypes and isolation sources. A total of 327 clinical isolates originated from different hospitals, were recovered from diverse clinical specimens collected from patients admitted to the ICU and non‐ICU wards. The isolates were characterized for their resistance phenotypes and biofilm formation capacities. Most A. baumannii isolates showed high resistance patterns against all examined antibiotics. Based on the resistance profiles, 81.2% and 12.3% of isolates were classified into…
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Taxonomy
TopicsAntibiotic Resistance in Bacteria · Nosocomial Infections in ICU · Antibiotic Use and Resistance