# Harnessing Polymeric Xerogels for Enhanced Wound Care: Properties, Mechanisms, and Applications

**Authors:** Amrita Kumari, Sweta Acharya, Gautam Singhvi, Ashwin Mali, Ankit Jain

PMC · DOI: 10.1021/acsmaterialsau.5c00134 · 2025-11-27

## TL;DR

This paper reviews how polymeric xerogels can improve wound care by managing exudate and promoting healing through their unique properties.

## Contribution

The paper provides a comprehensive review of xerogels' mechanisms and applications in wound healing, highlighting recent innovations and patents.

## Key findings

- Xerogels offer multifunctional benefits for wound care due to their biocompatibility and large surface area.
- They can be engineered into various forms like films and scaffolds for specific wound treatment needs.
- Xerogels support clot formation and tissue regeneration, especially in chronic and exudative wounds.

## Abstract

Wounds significantly impact an individual’s quality
of life,
necessitating a tailored approach to treatment based on the wound’s
stage of healing and condition. Exudate plays a natural role in recovery,
but excessive amounts can complicate wound management, creating a
need for advanced therapeutic solutions. Consequently, there is an
ongoing demand for advanced therapeutic solutions and innovative
wound care devices. Xerogels are
gaining recognition as promising materials in wound healing therapeutics
due to their unique properties and multifunctional applications. These
nanoporous materials, characterized by their large surface area and
biocompatibility, can be engineered using various polymers to enhance
their effectiveness for specific wound care applications. Their ability
to support clot formation and promote tissue regeneration makes them
particularly valuable for addressing exudative and chronic wounds.
This review offers an in-depth examination of emerging research on
xerogels in wound treatment, assessing the current landscape and identifying
potential applications of xerogels in various forms including films,
grafts, scaffolds, and particles. Additionally, we explore various
mechanisms of polymer-based xerogel function and summarize recent
patents related to this innovative technology. As research in this
area progresses, xerogels utilizing different polymers offer advanced
solutions for future wound care therapies.

## Full-text entities

- **Diseases:** Wounds (MESH:D014947)
- **Chemicals:** Polymeric Xerogels (-), polymer (MESH:D011108)

## Figures

12 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12810032/full.md

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Source: https://tomesphere.com/paper/PMC12810032