# Surface Plasmon Resonance Sensors Based on the Molecularly Imprinted Technique for Simvastatin Detection

## TL;DR

This paper introduces a new sensor using molecular imprinting to detect simvastatin with high sensitivity and accuracy.

## Contribution

A novel SPR sensor based on molecular imprinting for precise detection of simvastatin is developed and tested.

## Key findings

- The sensor has a linear detection range of 0.001–1.0 mg/mL for simvastatin.
- The sensor showed high selectivity against other statins like atorvastatin and rosuvastatin.
- Artificial plasma tests achieved approximately 99% recovery of simvastatin.

## Abstract

In this study, surface
plasmon resonance (SPR)-based sensors were
developed to determine simvastatin (SIM) with phosphate buffer (pH
7.4) using the molecular imprinting technique (MIT). SIM imprinted
(MIP) and nonimprinted (NIP) poly­(2-hydroxyethyl methacrylate-N-methacryloyl-l-tryptophan methyl ester) polymeric
films were synthesized onto the surface of the SPR chips to obtain
kinetic parameters. The characterization of the MIP and NIP sensors
was determined by contact angle and atomic force microscopy measurements.
The range of linearity was measured as 0.001–1.0 mg/mL for
SIM imprinted polymeric film-based SPR sensors. The selectivity of
SPR sensors for competitive adsorption of atorvastatin and rosuvastatin
was also investigated. After optimizing the experimental studies for
SIM determination, SIM determination was also performed in artificial
plasma solutions, and the recoveries were calculated to be approximately
99%. The findings indicate that SIM imprinted SPR sensors demonstrate
exceptional sensitivity and selectivity along with a remarkably low
detection limit for precise target identification.