# The neoadjuvant esophageal score: a prognostic tool for predicting survival and postoperative complications in esophageal squamous cell carcinoma

## TL;DR

A new scoring system called the NAE score helps predict survival and complications in esophageal cancer patients after treatment.

## Contribution

The NAE score is a novel prognostic tool derived from treatment response for esophageal squamous cell carcinoma.

## Key findings

- The NAE score effectively stratifies survival outcomes with higher scores indicating worse prognosis.
- A survival nomogram incorporating the NAE score showed strong discrimination and better predictive accuracy than TNM staging.
- The NAE score also reliably predicts postoperative complications when combined with surgical approach and alcohol consumption.

## Abstract

Esophageal squamous cell carcinoma (ESCC) remains a major global health challenge, and reliable prognostic markers. We developed and validated the Neoadjuvant Esophageal (NAE) score, derived from treatment response, to predict overall survival (OS) and postoperative complications in locally advanced ESCC.

We retrospectively analyzed 411 patients with ESCC from four hospitals who underwent esophagectomy following neoadjuvant therapy between July 2013 and November 2020. Patients were stratified into low-, intermediate-, and high-score groups. OS was assessed using Kaplan–Meier and Cox regression analyses, and predictive models were constructed with nomograms. Model performance was evaluated using concordance index (C-index), ROC curves, calibration plots, and decision curve analysis.

The NAE score effectively stratified survival outcomes (5-year OS, p < 0.001), with higher scores indicating worse prognosis. Adjuvant therapy provided a significant OS benefit only in the high-NAE group (p = 0.044), but not in the low- or intermediate-score groups. Multivariable Cox analysis confirmed the NAE score, perineural invasion, lymphovascular invasion, and neutrophil count as independent prognostic factors. A survival nomogram incorporating these variables demonstrated strong discrimination (C-index=0.742) and superior predictive accuracy compared with TNM staging (AUC 0.673–0.835 vs. 0.618–0.725). In addition, a complication-prediction nomogram integrating NAE score, surgical approach, and alcohol consumption reliably predicted major postoperative complications (C-index=0.789).

The NAE score is a robust prognostic tool for patients with locally advanced ESCC, capable of predicting survival, guiding adjuvant therapy, and estimating risk of severe postoperative complications. Its integration into clinical practice could refine risk stratification and support personalized treatment strategies, with prospective validation warranted.