# Functional decline after severe COVID-19: duke activity status index for preoperative risk assessment

**Authors:** Luis Alberto Rodriguez Linares, Sarah Cerillo Lopes

PMC · DOI: 10.3389/fmed.2025.1623423 · Frontiers in Medicine · 2026-01-02

## TL;DR

Severe COVID-19 leads to lasting functional decline, and the Duke Activity Status Index can help assess surgical risk in these patients.

## Contribution

This study demonstrates the utility of the DASI in evaluating functional decline in post-severe-COVID-19 patients for preoperative risk assessment.

## Key findings

- Severe COVID-19 survivors showed significantly reduced DASI scores post-infection.
- Pleural effusion and ultrasound abnormalities correlated with greater functional decline.
- DASI scores correlated with duration of intubation and hospital stay.

## Abstract

Survivors of severe COVID-19 (Coronavirus Disease 2019) frequently experience long-term functional impairment, a condition known as post-COVID syndrome. As these patients may eventually undergo surgical procedures, evaluating their functional capacity becomes essential for safe anesthetic management. The Duke Activity Status Index (DASI) is a validated, easy-to-administer tool that correlates with cardiopulmonary fitness and surgical risk.

To evaluate changes in functional capacity using DASI scores in patients who survived severe COVID-19, comparing pre- and post-infection performance, and to assess implications for perioperative care.

A retrospective observational study was conducted including 31 patients with a history of severe COVID-19 requiring ICU (Intensive Care Unit) admission. DASI scores were collected before and after hospitalization due to COVID-19. Associations between DASI variation and clinical variables (e.g., presence of pleural effusion, duration of intubation, ICU stay) were also explored.

A marked decline in functional capacity was observed after COVID-19, with lower DASI scores post-infection. The presence of pleural effusion and ultrasound abnormalities were associated with more pronounced reductions in DASI scores. A strong correlation was found between duration of intubation and length of hospital stay, and between post-COVID DASI and percentage variation.

Severe COVID-19 has a lasting impact on functional capacity as measured by DASI. These findings highlight the need for anesthesiologists to include functional assessments in the preoperative evaluation of patients with a history of severe COVID-19. Integrating DASI into routine pre-anesthetic workup may improve risk stratification and perioperative outcomes in this vulnerable population.

## Linked entities

- **Diseases:** Coronavirus Disease 2019 (MONDO:0100096)

## Full-text entities

- **Diseases:** COVID-19 (MESH:D000086382), pleural effusion (MESH:D010996), post-COVID (MESH:D000094024), Functional decline (MESH:D060825), long-term functional impairment (MESH:D000088562), infection (MESH:D007239)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12808341/full.md

## References

40 references — full list in the complete paper: https://tomesphere.com/paper/PMC12808341/full.md

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Source: https://tomesphere.com/paper/PMC12808341