# Electrophysiology of gliomas: current science, implications, and opportunities

## TL;DR

This review explores how gliomas interact with neurons, creating abnormal brain activity that can be studied with advanced electrodes to improve treatment.

## Contribution

The paper highlights novel electrophysiological signatures and high-density electrode technologies for studying gliomas.

## Key findings

- Gliomas create hyperexcitable conditions that promote tumor growth and neural circuit infiltration.
- High-density electrodes offer improved spatial resolution for detecting glioma-associated neural activity.
- Neuromodulation shows potential as a therapeutic strategy for gliomas and related epilepsy.

## Abstract

Gliomas engage in bidirectional communication with neurons, promoting hyperexcitable conditions that enable neural circuit infiltration and drive tumor growth. These neuron-glioma interactions create patterns of aberrant neural activity that can be detected using intracranial electrodes. While conventional clinical electrodes are limited by low spatiotemporal resolution and lack of single-unit precision, recent advances in neural engineering have introduced multiple types of high-density electrodes that provide orders of magnitude greater spatial resolution. Pairing these tools with emerging characterizations of novel, glioma-associated electrophysiological signatures offers new opportunities to understand disease progression and improve surgical and medical management for gliomas and glioma-related epilepsy. In this review, we begin by outlining foundational research in cancer neuroscience and neuron-glioma interactions through the lens of extracellular dynamics. We then discuss established and emerging methods for intraoperative evaluation of neural activity, what is known about glioma-associated oscillatory and aperiodic trends, and implications for future studies. Finally, we consider the therapeutic potential of neuromodulation for gliomas.