# The DO-KB knowledgebase 2026 update: expanding programmatic and language access **Authors:** J Allen Baron, Claudia M Sánchez-Beato Johnson, Michael A Schor, Dustin Olley, Lance Nickel, Victor Felix, Susan M Bello, Carol Greene, Richard Lichenstein, Katharine Bisordi, Rima Koka, Cynthia Bearer, Regina Macatangay, Nischal Ada, Kaitlin Ballenger, Emily Bliss, Lauren Colliver, Grace Dobbins, Harrison Heitzig, Shannan Dixon, Patrick Semesky, Jennifer Garth, Matthew Fairchild, Peter Gaskin, Sarina Zahid, Rachel Castillo, Sarah Edwards, Astrid Widjaja, Yamei Usui, Erin Lynch, Melissa Clarkson, Todd Detwiler, Lynn M Schriml PMC · DOI: 10.1093/nar/gkaf1213 · Nucleic Acids Research · 2025-11-26 ## TL;DR The DO-KB 2026 update improves access to disease data with new tools and expanded language support. ## Contribution New programmatic access tools and Spanish language support are introduced for the DO-KB. ## Key findings - DO-KB now includes a DO Nosology education program. - The DO website and ontology content have been translated into Spanish. - Disease knowledge representation has been expanded. ## Abstract The Human Disease Ontology Knowledgebase (DO-KB; https://disease-ontology.org/), a Global Core Biodata Resource, serves as a reference framework for multiscale biomedical data integration and analysis, within a unifying etiology-based disease classification. In this 2026 update of the Human Disease Ontology (DO) and DO-KB resource, we present significant advances in programmatic data retrieval and disease representation since our previous NARdb publication. Here we report on the development of a DO Nosology education program, the Spanish translation of the DO website and ontology content, and expansion of disease knowledge representation. Graphical Abstract ## Full-text entities - **Diseases:** Disease (MESH:D004194) - **Species:** Homo sapiens (human, species) [taxon 9606] ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12807653/full.md ## Figures 1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12807653/full.md ## References 26 references — full list in the complete paper: https://tomesphere.com/paper/PMC12807653/full.md --- Source: https://tomesphere.com/paper/PMC12807653