# Vulgar Verruca or Seborrheic Keratosis: A Clinical Challenge in Tattooed Skin

**Authors:** Carol E Marquez Maldonado, Lucia Achell Nava, Dolores M Arellano Vivero, Guadalupe Maldonado-Colin, Maria A Loredo Alanis

PMC · DOI: 10.7759/cureus.99397 · Cureus · 2025-12-16

## TL;DR

This paper discusses a case where a skin condition called seborrheic keratosis was mistaken for a wart in tattooed skin, emphasizing the need for accurate diagnosis.

## Contribution

The paper presents a rare case of seborrheic keratosis occurring in tattooed skin, highlighting its distinction from warts.

## Key findings

- A 47-year-old man with a history of pemphigus vulgaris developed seborrheic keratosis in tattooed skin.
- Dermoscopy and histopathology confirmed the diagnosis of seborrheic keratosis, not warts.
- The case suggests that trauma from tattoos can lead to seborrheic keratosis formation.

## Abstract

The development of verrucous lesions within tattoos poses a common diagnostic challenge, primarily between verruca vulgaris and the rarely reported phenomenon of Koebner-induced seborrheic keratosis (SK). We present the case of a 47-year-old man with a history of pemphigus vulgaris who developed multiple, brown, warty papules meticulously following the pattern of existing black ink tattoos on his trunk and shoulder. Dermoscopy revealed a cerebriform pattern with fissures, ridges, and milia-like cysts, classic for SK. Histopathological examination confirmed the diagnosis, demonstrating acanthosis, papillomatosis, hyperkeratosis, and corneal pseudocysts. No significant hypergranulosis or dilated capillaries within the dermal papillae were observed. Although HPV genotyping was not available, the overall clinicopathologic correlation supported a diagnosis of SK. This case highlights that SK may arise along tattoo tracts through trauma-related mechanisms and should be carefully distinguished from verruca vulgaris to avoid misdiagnosis and unnecessary interventions.

## Linked entities

- **Diseases:** pemphigus vulgaris (MONDO:0008219), verruca vulgaris (MONDO:0001209), seborrheic keratosis (MONDO:0008420)

## Full-text entities

- **Diseases:** corneal pseudocysts (MESH:D010192), trauma (MESH:D014947), SK (MESH:D017492), hyperkeratosis (MESH:D017488), acanthosis (MESH:D000052), verrucous lesions (MESH:D018289), papules (MESH:D000169), pemphigus vulgaris (MESH:D010392), papillomatosis (MESH:D010212), verruca vulgaris (MESH:D014860)

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12807534/full.md

## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC12807534/full.md

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Source: https://tomesphere.com/paper/PMC12807534