# TBCancer: A database for exploring characteristics and functions of tissue‐biased genes in cancer

## TL;DR

This paper introduces a database of tissue-biased genes in cancer, showing how their inactivation contributes to cancer progression and could aid in developing new treatments.

## Contribution

The novel contribution is the identification and integration of multi-omics data for 10,921 tissue-biased genes across 54 tissues and 41 cancers.

## Key findings

- Tumor-associated tissue-biased genes are often downregulated, mutated, or epigenetically modified.
- Inactivation of these genes promotes cancer by increasing stemness and immune evasion.
- The database provides a resource for exploring these genes' roles in cancer mechanisms and therapies.

## Abstract

This study defined 10,921 tissue‐biased genes across 54 normal tissues and 41 cancer types. Tumor‐associated tissue‐biased genes exhibit downregulation, mutations, and epigenetic modifications, correlating with poor clinical outcomes. Their inactivation promotes tumorigenesis by enhancing stemness and immune evasion, highlighting their value as prognostic biomarkers and therapeutic targets. To facilitate research, we developed a database integrating multi‐omics data on these genes for mechanistic and therapeutic exploration.