# Cancer-Induced Neuropathic Pain: Clinical Features and Treatment Options

**Authors:** Stefano Barbaro, Laura Lanotte, Ester Scapini, Antonio Zagaria, Pierdomenico Carone, Gennaro Gadaleta Caldarola, Maddalena Vurchio, Michele Debitonto

PMC · DOI: 10.7759/cureus.99374 · Cureus · 2025-12-16

## TL;DR

Cancer-related nerve pain causes severe discomfort and needs a combination of treatments to manage effectively.

## Contribution

This paper outlines clinical features and treatment strategies for cancer-induced neuropathic pain.

## Key findings

- Cancer-induced neuropathic pain is difficult to control and affects quality of life.
- Multimodal treatment with adjuvant analgesics improves management of this pain.
- Ongoing assessment is necessary to adjust interventions and ensure patient comfort.

## Abstract

Cancer-induced neuropathic pain results from tumor or treatment-induced damage to the somatosensory system. Manifesting as burning, shooting, or electric-like sensations, it is challenging to control and can significantly reduce the quality of life. Effective management requires a multimodal approach, using adjuvant analgesics such as anticonvulsants or antidepressants alongside standard therapies. This condition often persists after cancer treatment and necessitates ongoing assessment to determine therapeutic response and adjust interventions for optimal patient comfort and function.

## Linked entities

- **Diseases:** cancer (MONDO:0004992)

## Full-text entities

- **Diseases:** Neuropathic Pain (MESH:D009437), Cancer (MESH:D009369)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12805923/full.md

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Source: https://tomesphere.com/paper/PMC12805923