First person – Nayeli Reyes-Nava

TL;DR

This paper discusses the interaction of ciliopathy proteins Lrrc56 and Odad3 in controlling axonemal dynein deployment in multiciliated cells.

Contribution

The study reveals a novel physical and functional interaction between Lrrc56 and Odad3 proteins in ciliary function.

Findings

Lrrc56 and Odad3 interact to control axonemal dynein deployment in multiciliated cells.

The interaction is crucial for the trafficking of large ciliary protein complexes into cilia.

Abstract

First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping researchers promote themselves alongside their papers. Nayeli Reyes-Nava is first author on ‘
Physical and functional interaction of the ciliopathy proteins Lrrc56 and Odad3 control deployment of axonemal dyneins in vertebrate multiciliated cells’, published in DMM. Nayeli is a postdoc in the lab of John Wallingford and Edward Marcotte at the University of Texas at Austin, Austin, TX, USA, investigating how large ciliary protein complexes are trafficked into cilia to reveal the molecular basis of ciliopathies.

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