# Spontaneous Heparin-Induced Thrombocytopenia Following Orthopedic Surgery

**Authors:** Aleksey Korolyov, Rong Hu

PMC · DOI: 10.7759/cureus.99312 · 2025-12-15

## TL;DR

This paper presents a rare case of spontaneous HIT in an elderly patient after knee replacement surgery, without prior heparin exposure.

## Contribution

The novelty lies in reporting a rare occurrence of spontaneous HIT following orthopedic surgery without heparin exposure.

## Key findings

- An 83-year-old patient developed HIT after knee replacement surgery without prior heparin exposure.
- The case highlights the importance of considering spontaneous HIT in postoperative patients with unexplained thrombocytopenia.

## Abstract

Heparin-induced thrombocytopenia (HIT) is a life-threatening complication most commonly associated with exposure to heparin. Timely recognition of suspected HIT is vital, as early intervention is associated with improved outcomes and a decreased mortality rate. Spontaneous HIT is a rare form that occurs in the absence of heparin exposure. Here, we report the case of an 83-year-old patient diagnosed with spontaneous HIT after undergoing knee replacement surgery.

## Linked entities

- **Diseases:** thrombocytopenia (MONDO:0002049)

## Full-text entities

- **Diseases:** HIT (MESH:C562865), Thrombocytopenia (MESH:D013921)
- **Chemicals:** Heparin (MESH:D006493)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12805603/full.md

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Source: https://tomesphere.com/paper/PMC12805603