H-SPAR DB: human spaceflight platform for analysis and research—an integrative omics database for space health

TL;DR

H-SPAR DB is a new database that helps researchers study space health by combining and analyzing biological data in one easy-to-use platform.

Contribution

H-SPAR DB introduces an integrative omics database with streamlined workflows for spaceflight biology research.

Findings

H-SPAR DB integrates curated molecular lists and transcriptomic datasets into a unified platform.

The database supports differential expression analysis and association analyses with interactive visualizations.

It reduces data gathering time and enhances the efficiency of space biology research.

Abstract

H-SPAR DB is a comprehensive database designed to support space health research by providing a unified platform for data integration, analysis, and interpretation. The database simplifies the complex workflows associated with spaceflight-related biology studies by combining curated molecular lists, transcriptomic datasets from NASA’s GeneLab, and user-uploaded data into a streamlined, user-friendly interface. H-SPAR DB enables researchers to perform differential expression analysis, set operations, and association analyses while also generating integrative knowledge graphs around a space-related biological theme. The platform reduces the time required for data gathering and processing by offering a single platform for data exploration, analysis, and visualization. By integrating interactive visualizations and data tables, H-SPAR DB facilitates the interpretation of results, ultimately enhancing the efficiency of space biology research and fostering discoveries that address human health challenges in space. Researchers can access H-SPAR DB freely at https://bioinformatics.cing.ac.cy/H-SPARDB/ without login or other requirements.

Graphical Abstract

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