Systematic review and meta-analysis of cardiac complications in acute pancreatitis
Veronika Lillik, Mahmoud Obeidat, Dániel Sándor Veres, Péter Ferdinandy, Elizabet Bodó, Asal Pourrastegar, Ali Moradi, Péter Hegyi, Rita Nagy
TL;DR
This study finds that heart conditions like atrial fibrillation and heart failure significantly increase the risk of death in patients with acute pancreatitis.
Contribution
The paper systematically links specific cardiac abnormalities to acute pancreatitis outcomes using a large-scale meta-analysis.
Findings
Atrial fibrillation triples the odds of death in acute pancreatitis patients.
Severe acute pancreatitis is associated with ECG repolarization changes.
Pre-existing heart failure increases mortality risk in acute pancreatitis.
Abstract
Cardiovascular abnormalities are associated with acute pancreatitis (AP). Here, we temporarily link these abnormalities to AP outcomes. We systematically searched PubMed, EMBASE, and Cochrane on 5th November 2023 and included 44 studies (n = 5.3 million patients, 63.8% retrospective) containing United States National Inpatient Sample cohorts, where overlap may occur; without these databases, 1.2 million patients remained. We analyzed chronic heart failure (CHF), atrial fibrillation (AF), repolarization changes, and QTc prolongation on ECG in association with mortality and severity using odds ratios (ORs) and mean differences (MDs) with 95% confidence intervals (CIs) in a random-effects model. AP patients with AF face 2.69-fold increased odds of mortality in AP (OR, 2.69; CI, 1.34–5.38). Severe and moderately severe AP ([M]SAP) is associated with 2.75-times higher odds of repolarization…
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Taxonomy
TopicsPancreatitis Pathology and Treatment · COVID-19 Clinical Research Studies · IgG4-Related and Inflammatory Diseases