# SportsXbiodata: A web platform for integrative analysis of exercise-induced gene and protein expression

## TL;DR

SportsXbiodata is a free web platform that integrates multi-omics data and literature to study molecular changes caused by exercise.

## Contribution

The novelty lies in compiling and integrating multi-omics datasets and exercise-related literature within a systems biology framework.

## Key findings

- The platform includes 2,563 multi-omics datasets and 3,600 exercise-related publications.
- It supports modules for gene/protein/metabolite profiling, immune infiltration, and phenotype-gene correlation analysis.
- Users can freely access and download standardized datasets and analysis results.

## Abstract

Exercise can induce extensive molecular adaptations across multiple tissues; however, existing databases primarily focus on transcriptomic data and lack the ability to integrate multi-omics evidence and literature within a systems biology framework. To address this limitation, we developed SportsXbiodata, an open-access multi-omics integration platform that compiles 2,563 public multi-omics datasets and 3,600 exercise-related publications. The platform provides comprehensive functional modules for gene/protein/metabolite expression profiling, immune infiltration analysis, phenotype-gene correlation analysis, knowledge graph analysis, literature-based gene exploration, and exercise-drug homology analysis. It also supports data querying, visualization, and user-defined enrichment analysis for exercise-related datasets. SportsXbiodata is completely free and accessible without registration, allowing users to directly download standardized datasets and analysis results, thereby promoting transparency and reproducibility in scientific research.

•SportsXbiodata integrates 2,563 multi-omics datasets and 3,600 exercise-related studies•The platform provides comprehensive modules for expression, immune, phenotype and analyses•Visualization, GSEA, and multi-omics integration are supported

SportsXbiodata integrates 2,563 multi-omics datasets and 3,600 exercise-related studies

The platform provides comprehensive modules for expression, immune, phenotype and analyses

Visualization, GSEA, and multi-omics integration are supported

Health sciences