Dinutuximab beta effectively treats Ewing sarcoma when combined with chemotherapy
Roberta Frapolli, Marina Meroni, Ezia Bello, Lorenza Pirona, Elisa Callegari, Valentina Kebede, Isabella Pellerani, Simone Canesi, Eugenio Scanziani, Uta Dirksen, Patrizia Angelico, Stefano Biondi, Matteo Malinverno
TL;DR
Dinutuximab beta, when combined with chemotherapy, significantly reduces tumor growth and improves survival in a mouse model of Ewing sarcoma.
Contribution
The study demonstrates the synergistic efficacy of dinutuximab beta and chemotherapy in treating Ewing sarcoma.
Findings
Dinutuximab beta suppressed tumor growth by 60% and improved survival by 68% in a mouse model.
Combination therapy with doxorubicin enhanced tumor suppression to 86% and survival extension to 146%.
Dinutuximab beta recruits immune cells to induce tumor cell death.
Abstract
Ewing sarcoma is a rare and aggressive cancer of the bone and soft tissues primarily affecting children and young adults. Prognosis for patients with metastatic or recurrent disease remains poor despite intensive multimodal therapy, highlighting the need of novel therapeutic approaches. The disialoganglioside GD2 is highly expressed on Ewing sarcoma cells, making this tumor eligible for anti-GD2 immunotherapy with dinutuximab beta. Through in vitro and in vivo approaches, this study demonstrated that dinutuximab beta effectively suppressed tumor growth by 60% (p = 0.0135) and improved survival rate by 68% (p = 0.0006) in a mouse model xenograft. The combination therapy with doxorubicin demonstrated superior efficacy compared to monotherapy, with enhanced tumor suppression (86%; p = 0.0009) and an extension of survival rate (146%; p = 0.000025). This study showed that dinutuximab beta,…
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Taxonomy
TopicsNeuroblastoma Research and Treatments · Sarcoma Diagnosis and Treatment · Glioma Diagnosis and Treatment