# Administration of Desloratadine for Postorgasmic Illness Syndrome in a Japanese Teenager

## TL;DR

A Japanese teenager with a rare condition causing illness after ejaculation was successfully treated with desloratadine.

## Contribution

This is the first reported case of postorgasmic illness syndrome treated with desloratadine.

## Key findings

- Symptoms of postorgasmic illness syndrome in a 17-year-old boy improved after desloratadine treatment.
- The patient's general malaise and other symptoms after ejaculation disappeared following treatment.
- Desloratadine may be a potential treatment for postorgasmic illness syndrome.

## Abstract

Postorgasmic illness syndrome is a rare condition occurring after ejaculation. This syndrome can significantly affect the quality of life of patients.

A 17‐year‐old boy suffered from annoying fatigue, headache, photophobia and the sensation of a flu‐like state. He did not know the trigger of these symptoms. He visited a psychiatry clinic where he was diagnosed with depression. Although he received administration of selective serotonin reuptake inhibitors, his symptoms continued. Then he noticed that his symptoms occurred after ejaculation by masturbation or wet dreams. He visited our outpatient clinic when he was 19 years old. We administered desloratadine. One month later the general malaise after ejaculation improved. Thereafter, all symptoms after ejaculation disappeared.

A Japanese teenager suffering from postorgasmic illness syndrome was successfully treated with desloratadine. We believe that our experience will contribute to elucidating and treating this condition in the future.

Postorgasmic illness syndrome (POIS) is a rare syndrome occurring after ejaculation. We report a case of POIS treated with desloratadine, which, to the best of our knowledge, is the first use of this treatment for POIS.